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The STEP UP Phase 3b clinical trial, published in The Lancet Diabetes and Endocrinology in 2025, enrolled over 1,400 adults with obesity and without diabetes
At the same time, pharmaceutical companies have faced increasing public and regulatory pressure to lower self-pay (cash) prices for these medications though pricing and discount programs vary by drug and pharmacy
They eat less because they no longer enjoy it, and lose weight from the simple loss of caloric intake
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