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In the Bridge-TIMI 73a study involving patients with hypertriglyceridemia and the BALANCE study focusing on patients with familial chylomicronemia syndrome, Olezarsen significantly lowered plasma triglyceride levels without causing major safety issues

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The mechanisms by which amino acid metabolism regulates macrophage polarization in IBD are not confined to cells alone, and the abundant gut microbiota provide a basis for microbiota-cell metabolic interactions