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Gallbladder disease GLP1related agents are associated with higher gallstone risk
This can cause our natural "reservoir" of glutathione to run low
A landmark 2-year randomized, double-blind, placebo-controlled trial (Nass et al., Annals of Internal Medicine, 2008, N=65 healthy elderly adults aged 60-81) demonstrated that 25 mg/day MK-677 restored GH and IGF-1 secretory profiles to levels characteristic of healthy young adults
13 Two meta-analyses of other GLP-1 RA CVOTs found that GLP-1 RAs were associated with greater rates of DR progression, but both studies found that the effect was driven by the extent of hemoglobin A1c reduction, rather than the medications themselves
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