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Human data is still limited, so individual results vary which is exactly why this is done with monitoring rather than guesswork
We suggest regular blood tests to check: Serum Vitamin B12 levels Methylmalonic acid (MMA) and homocysteine levels Complete Blood Count (CBC) to monitor for signs of anemia These results help us adjust the dose
For instance, doxorubicin, a topoisomerase inhibitor, induces DNA damage in cancer cells by interfering with topoisomerases and unwinding supercoiled DNA 24
A study by Bowers et al
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