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Synaptic dysfunction underlying NPS in AD Synaptic dysfunction, a hallmark of AD, plays a crucial role in the NPS observed in various AD models, including 3xTg, APP/PS1, and hAPP J20 models

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Calmangafodipir (PledOx) that is developed from mangafodipir, could relieve the oxidative stress via mimicking the activity of MnSOD and thereby prevent OXA-induced mechanical allodynia, cold thermal hyperalgesia, and the reduction in intraepidermal nerve fiber (IENF) density in a BALB/c mouse model of PIPN

Those can help support mental health too. Dr