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As of 2024, the MHRA (Medicines and Healthcare products Regulatory Agency) has authorised Mounjaro for use in adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity, such as hypertension, dyslipidaemia, or obstructive sleep apnoea

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Cardiovascular effects incretin-based therapies have been associated with modest increases in heart rate