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24,25 It is important to note that the magnitude of benefit on total eGFR slope (~0.75 mL/min/1.73 m 2 /y) in participants receiving and not receiving SGLT2 inhibitors is clinically meaningful, and consistent with an effect size that is highly likely to translate to benefit on clinical kidney end points, based on the work of the CKD-Epidemiology Clinical Trials Consortium
Canadian patients might access it via online peptide suppliers (with all the caveats that entails) or cross-border if they have a U.S
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