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martiniquensis , AmB resistance is linked to increased metacyclogenesis, growth, and infectivity, with resistant strains persisting longer in mice without causing clinical disease

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To further characterize these interactions, we constructed a molecular interaction network (Figure 7C) revealed three functionally interconnected modules: (Young et al., 1990) an oxidative stress module linking Gpx3 with glutathione metabolites, and ( Consistent with multi-omics findings, KEGG pathway analysis identified glutathione metabolism as the most significantly perturbed shared pathway (Figure 8A), exhibiting coordinated changes between upregulated antioxidant enzymes such as Gpx3 and Mgst1 alongside depleted glutathione derivatives, supporting redox imbalance as a key pathogenic feature