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Pyridoxine (B) in high doses is known to interact with certain drugs: it can reduce the therapeutic efficacy of levodopa by increasing peripheral conversion of levodopa to dopamine (vitamin B speeds up decarboxylation)

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For this purpose, multiple solutions are available, including bacteriostatic water, sterile water for injection, dextrose 5% in injection, and normal saline for injection

Even when the diagnosis is correct, the absence of a lab result supporting that diagnosis creates a medical necessity audit vulnerability