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It presents a lipid- and water-soluble substance meaning that it is active in both hydrophobic and hydrophilic environments (i.e
10.1016/j.jjcc.2021.09.005 J
Post-transcriptional control of gene expression following stress: the role of RNA-binding proteins
Similarly, in vitro exposure of macrophages to 10 M of ACh prior to endotoxin challenge reduces TNF- production by increasing adenylyl cyclase 6 activity, leading to cAMP formation, CREB phosphorylation, and the expression of c-Fos, a known inhibitor of TNF transcription ( It is worth noting that the different choline dietary forms differ in their effect
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