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This concept is reinforced by the fact that most of these neurons co-express NPY and Agouti-related peptide (AgRP, another important regulator of metabolic homeostasis), and more importantly, there is an insulin/NPY network that regulates energy homeostasis, so that the lack of insulin signaling in NPY neurons induces an increase in energy reserves and obesity and also produces an alteration of GH/IGF-I axis

Patience through this phase is essential

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