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245 Sleep loss is known to activate the bodys stress signaling network, which can further aggravate sleep disruption

Conversely, heart failure with reduced ejection fraction (HFrEF) patients with ischemic or chemotherapy-induced cardiomyopathy may derive greater benefit from mitochondrial protectants or transplantation strategies

Inflammation, on the other hand, is the organisms defense mechanism against pathogens or tissue damage, initiated through cytokines, chemokines, and other mediators