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Antagonising glucagon receptors (GCGRs) with modified glucagon analogues, small molecules or antisense oligonucleotides has also been problematic because of the risk of hypoglycaemia and adverse effects on liver function, including steatosis and an increase in LDL-cholesterol

SGLT2is decrease plasma glucose levels through inhibition of renal glucose reabsorption in the proximal tubule, which results in increased glucose excretion by the kidneys

Gauge sizes measure the diameter or thickness of a needle

Metformin is usually the first-line treatment for Type 2 Diabetes due to its long-term safety and cost-effectiveness