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Women The ENDO 2025 data also identified female sex as a risk factor for greater lean mass loss on semaglutide

By amplifying both pathways, tirzepatide often provides stronger appetite control and metabolic support than single-hormone options

The study, which analyzed over one decade of data from more than 1.5 million patients with Type 2 diabetes, looked at 13 types of cancer associated with obesity, including esophageal, breast, colorectal, endometrial, gallbladder, stomach, kidney, ovarian, pancreatic, and thyroid cancer as well as hepatocellular carcinoma, meningioma, and multiple myeloma

For the newer semaglutide-and-tirzepatide subgroup it was 0.8 kg per month, based on 10 arms and 1,776 participants