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Extended-release exenatide (Bydureon) uses a microsphere depot formulation that provides sustained release over time, allowing for weekly dosing despite different pharmacokinetics from other weekly agents
This quality assurance approach supports the advancement of research by controlling and documenting experimental variables related to compound quality
NCT01800968), with or without T2D, and the randomized placebo-controlled parallel group LIVE study (NCT01472640) of 241 patients with HF (LV EF 45%), with or without T2D, found that liraglutide (vs placebo), over 180 days and 24 weeks, respectively, did not change LV EF on echocardiogram
Pardi P, Kharitonov SA, Barnes PJ: Elevation of exhaled ethane concentration in asthma
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