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Similar content being viewed by others Subjects Facts Introducing PANoptosis and constructing a comprehensive network of cell death mechanisms The key role of ROS metabolic imbalance in the occurrence, development and treatment resistance of breast cancer Taking ROS as the core node connecting cell death pathways and therapeutic strategies Exploring innovative therapeutic strategies targeting the ROS-cell death network, providing a new direction for the precise treatment of breast cancer Open questions Can we design epigenetic triggers to selectively prime resistant cells for programmed cell death execution

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