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According to a recently proposed hierarchical oxidative stress model, [8, 9] a low level of oxidative stress, such as exposure to diesel exhaust products for 6 hours at a concentration of 10 to 50 g/mL, [10] leads to the activation of the transcription factor, nuclear erythroid 2 p45-related factor 2 (Nrf2), which encodes more than 200 genes
Confirming the important role of the TGF/SMAD pathway in pancreatic fibrosis, we found that high glucose promoted the activation of PSCs in vitro
Science 381 (6660), 851856
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