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These types of patents typically have the broadest scope

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The potency and duration of action of an N-(3-phenyl-1,2,4-thiadiazol-5-yl) piperazine analog, discovered through high-speed analog synthesis, were enhanced via structural optimization

Exendin 939 does not affect TRPV1 activation via protons, suggesting its mode selectivity As the inhibitory effect of exendin 939 on CAP-induced activation of TRPV1 was confirmed, its effect on proton-induced activation of TRPV1 was also tested via patch-clamp recordings and calcium imaging