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For instance, an 8-week double-blind controlled trial showed that when the subjects used a cream containing 2% L-carnitine daily and combined it with aerobic exercise three times a week, the average local fat thickness decreased by 12%-18%, and the proportion of fatty acid oxidation increased by approximately 15%-20%
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This sensitivity may be explained by the essential role of the placenta in coordinating endocrine, growth, and metabolic functions in response to intrauterine environmental cues
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