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That uncertainty is precisely why it remains an interesting research tool rather than a settled one, and it is stated plainly here rather than papered over with confident mechanism claims

IgE binds to mast cells, triggering the release of histamine and cysteinyl leukotrienes, which contribute to bronchoconstriction, edema, and mucus hypersecretion [26]

Damage to nerve tissue (peripheral neuropathy), leading to pain, numbness, and weakness in extremities: These can be caused by the vitamins role in the proper functioning of the nervous system

Hakim, M., Kurniani, N., Pinzon, R., Tugasworo, D., Basuki, M., & Haddani, H