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A particular challenge will be the transition from pre-clinical to clinical studies, since there are likely to be species differences
Van Guelpen B, Hultdin J, Johansson I, et al
The Phase 2 trial (NEJM 2023) reported an average body-weight reduction of about 24% at 48 weeks at the highest dose
This common concern affects many patients starting glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), or dulaglutide (Trulicity) for type 2 diabetes or weight management
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