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A decline in the dendritic spine density (DSD) is an early characteristic feature of many neurodegenerative diseases (Fiala et al., 2002
Moreover, viral vector gene transfer has been tested pre-clinically and is more promising because it provides a more efficient transcription transfer than non-viral methods
More importantly, the fusion image is displayed on a high-definition screen by integrating the fluorescent signal from the fluorescent dyes with standard unaided vision using white light imaging, thanks to advanced imaging system software
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