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Although several studies have investigated GLP-1RAs across mood and anxiety disorders, evidence appears mixed, as beneficial, harmful and null effects have all been reported for depressive symptoms and suicidality

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Everyone is different and may not experience nausea or any side effects from both semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro and Zepbound)

This would be in line with preclinical observations that incretin receptor expression is down-regulated by exposure to high glucose, and improves once normoglycaemia is restored (48), and that dys-regulation of glycaemic control in otherwise healthy humans leads to impaired incretin actions (49)