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In addition to these canonical reactions, both enzymes have been proposed to produce H 2 S by utilizing alternative substrates, namely, a combination of cystine and homocysteine for CBS and either cysteine or homocysteine for CSE (Sbodio et al., 2019)
Oral bioavailability is negligible due to gastrointestinal degradation
These forms can be taken in tablet form and bypass potential barriers caused by genetic variants
Alpha-lipoic acid, vitamin C, and vitamin E are added to enhance its bioavailability
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