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Second, a reduction in tubular reabsorption of both free carnitine and acylcarnitine has been reported during VPA treatment [45, 46], Third, VPA reduces endogenous synthesis of carnitine by blockade of the enzyme butyrobetaine hydroxylase

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Their standard needle gauge (26-27G) is coarser than insulin syringe needles, causing more discomfort

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Semaglutide (Ozempic, Wegovy) Semaglutide constipation rates run around 24-29% in clinical trials

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