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3 , e2020836 (2020)

When estrogen is too low or fluctuating (common during perimenopause/menopause), the body can store more fat, especially around the midsection, and insulin sensitivity can decline, which may slow weight loss progress even with GLP-1s

SARS-CoV-2 infection can disrupt the adhesion and tight junctions between the endothelium and intestinal epithelium, leading to dysbiosis of the intestinal flora and immune activation (Guo et al., 2021)

True, lasting lifestyle transformations dont happen through restrictive, self-guided fads or faceless online subscription services
