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[11] The risk here isnt usually lack of efficacy
We confirmed the effect of methotrexate (MTX), a folate biosynthesis inhibitor, on the expression of cell cycle genes
Tumor risk via p53 pathway interference Mitigate risk by: Careful patient selection: exclude patients with pre-existing active malignancy or high tumour risk (e.g., known p53 mutations, familial cancer syndromes)
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