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However, mitochondrial dysfunction can lead to a buildup of ROS due to an imbalance in their production and degradation 4,5 Another major source of ROS is NADPH oxidase (Nox), a membrane-bound enzyme complex that produces superoxide by transferring an electron to oxygen from NADPH

High hepatic fat content is the important inducement of the impairment of redox imbalance and insulin resistance

Liraglutide treatment prevented functional decline within the default mode network structures in contrast to placebo, further suggesting that GLP-1 receptor agonists can exert neuroprotective effects in AD and provide a promising disease-modifying strategy

2015;386(9992):461-468 Singla R, Gupta Y, Khemani M, Aggarwai S