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Ive had patients tell me that after starting GLP-1 therapy, they no longer experience cravings for alcoholsomething neither they nor I expected. GLP-1s for Weight Loss: A Long-Term Commitment While GLP-1s have been beneficial for many, they are not a one-size-fits-all solution
Subgroup analyses revealed important differences based on comparator drugs: GLP-1RAs demonstrated greater effectiveness than SGLT2 inhibitors in preventing MALOs (IRR: 0.93, 95%CI: 0.87-0.99, P = 0.043), than DPP-4 inhibitors in preventing hepatic decompensation events (IRR: 0.74, 95%CI: 0.66-0.83, P = 0.003), and than insulin therapy in averting HCC development (IRR: 0.32, 95%CI: 0.13-0.80, P = 0.033) [64]
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That level of weight loss, particularly when achieved over 3-4 months, significantly accelerates bone mineral density decline
