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Seek immediate medical attention (call 999 or attend A&E) if you experience: Loss of consciousness or fainting episodes , as these may indicate severe hypotension, cardiac arrhythmia, or profound hypoglycaemia Chest pain, palpitations, or shortness of breath accompanying lightheadedness, which could suggest cardiovascular complications Severe confusion, slurred speech, or weakness , particularly if you have diabetes, as these may indicate severe hypoglycaemia requiring urgent treatment Signs of stroke remember FAST: Face drooping, Arm weakness, Speech difficulties, Time to call 999 Persistent vomiting or diarrhoea preventing oral fluid intake, risking severe dehydration and electrolyte disturbances Contact your GP or diabetes specialist nurse within 24 hours if you experience: Frequent episodes of lightheadedness (multiple times daily) that interfere with daily activities or increase fall risk Lightheadedness accompanied by recurrent low blood glucose readings (below 4.0 mmol/L), particularly if you take insulin or sulfonylureas Postural symptoms that persist despite adequate hydration and rest Signs of dehydration including reduced urine output, persistent thirst, or dark urine Any lightheadedness that concerns you or represents a change from your usual state If you're experiencing symptoms and are unsure whether they require urgent attention, contact NHS 111 for advice

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IL-1 and GM-CSF are key mediators of trained immunity (180)