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In some cases, notably for older drugs that lost their patents years ago but still hold orphan drug exclusivity for a narrow indication, regulatory exclusivity is the only barrier remaining

This is the second large and under-discussed divergence between the DSIP literature and contemporary practice, and it compounds the dose gap described above

Some lean mass can be lost during any type of weight loss, especially when calories or protein are too low

(14) These emerging connections between GLP-1 signaling and skeletal physiology present a biologic rationale for how GLP-1 receptor agonists have potential to not only assist in weight management, but also favorably influence bone health and remodeling