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Homotaurine Limits the Spreading of T Cell Autoreactivity within the CNS and Ameliorates Disease in a Model of Multiple Sclerosis. Scientific Reports, vol

It would be interesting to metabolically test the hypothesis whether ferroptosis inducers heavily engaged the DMAPP-tRNASelCys-GPX4 branch response that would explain the higher sensitivity to RSL3 of cells expressing UBIAD1, being the metabolic mevalonate pathway of the cells fully rewired to synthetize CoQ 10 instead of GPX4

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Blood Pressure & Lipids Patients on these therapies often see a significant drop in systolic blood pressure and improvements in their lipid panels (triglycerides and ApoB), likely due to improved insulin sensitivity