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Where obesity is comorbid with BED, this parity framework may support GLP-1 or behavioral treatment coverage

Compensatory changes in the levels of weight-regulating hormones such as leptin, ghrelin, peptide YY, and gastric inhibitory peptide can counteract diet-induced weight loss, highlighting the difficulty in maintaining weight loss through diet alone [11]

The main outcome was hospitalization for heart failure and other outcomes were MACE outcomes (cardiovascular mortality, myocardial infarction, stroke, and all-cause mortality), metabolic outcomes (changes in HbA 1 c, weight, fasting plasma glucose (FPG)), and safety outcomes (severe adverse events, nausea, diarrhea, severe hypoglycemia, urinary tract infection, adverse events-related discontinuation)

Oral melanotic macules are brown-to-black benign lesions related to increased production of melanin in the basal cell layer of the epithelium