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Fracture Risk Data from GLP1 Trials Several cardiovascular outcomes trials (CVOTs) have collected fracture data as secondary outcomes: Trials involving semaglutide and dulaglutide generally report fracture rates similar to placebo A few studies suggest a potential increase in non-vertebral fractures, though findings are inconsistent and often not statistically significant One important confounder is weight loss, which itself can lead to bone loss

Nerve injuries: Nerve regeneration is slower, typically requiring 612 weeks to see meaningful improvements

Understanding how semaglutide makes you feel throughout the injection cycle helps you plan protein intake around your natural appetite patterns

Handb Exp Pharmacol 2010: 369405