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A systematic review confirmed that NAC improves ovulation rate and hormonal parameters in PCOS (Thakker et al., Obstet Gynecol Int, 2015) [59]
Moreover, the results in this study are indirectly interpreted by converting the expression level of GLP1R /GIPR/GCGR into the fluctuation of HbA1c to reflect the effect of GLP-1R-based agonists on each outcome, which may exacerbate the estimated effect to some extent
However, they may offer a more flexible and accessible option for patients when commercially available treatments are not suitable or available
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