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Switch TB-500 to GHK-Cu When: The injury is chronic (greater than 12 weeks old) rather than acute The primary deficit is collagen quality or tensile strength, not cell migration The patient shows signs of excess inflammation (TB-500's pro-angiogenic and MMP-upregulating effects may worsen inflamed, overactive wounds) Repeat imaging or clinical assessment shows vascularization is adequate but tissue matrix remodeling is incomplete A 2017 double-blind RCT published in the Journal of Wound Care (N=65) found that topical GHK-Cu significantly improved chronic wound closure at 12 weeks compared to placebo (63% vs