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Byrne AJ, Maher TM, Lloyd CM

Several other indications are under study, including obstructive sleep apnea, MASLD, knee osteoarthritis, chronic kidney disease, and cardiovascular outcomes

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Although the ELIXA studythe only CVD outcome trial of GLP-1 RAs published to datereported a neutral cardiovascular effect of lixisenatide, the potential cardiovascular benefits of GLP-1 RAs should not be overlooked, because high-risk subjects with established CVD were recruited in this study to delineate its cardiovascular safety within a short-term period