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Regulatory and Ethical Context The FDA has approved recombinant human IGF-1 only as mecasermin (Increlex) for the narrow indication of severe primary IGF-1 deficiency or GH-gene deletion with neutralising antibodies to GH, in children [15]

Findings suggest this interaction may trigger signal cascades involving second messengers such as cAMP, leading to downstream transcriptional activity related to GH synthesis

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Interestingly, GEP12 elicited stronger increases in the ISR (Fig