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A second family, BPC-157 and TB-500, targets tissue repair rather than the GH axis: BPC-157 is proposed to work through angiogenesis, nitric-oxide signaling, and anti-inflammatory activity, while TB-500 binds actin to promote cell migration, blood-vessel formation, and collagen deposition

Claimed outcome NAD+ changes Evidence level Cell and animal evidence What research currently shows Blocking NNMT can preserve nicotinamide, a building block used to make NAD+

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