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Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) have a boxed warning contraindication for semaglutide and tirzepatide, based on thyroid C-cell tumor findings in rodents [17]

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Background use of mineralocorticoid antagonists and sodium-glucose cotransporter 2 inhibitors was not common

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