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4.2 Dysbiotic microbiome stimulates cyclooxygenase-2 expression, affects gastric emptying, and induces GERD Cyclooxygenase-2 (COX-2) is the rate-limiting enzyme that catalyzes the initiating step in the metabolism of arachidonic acid to prostaglandin H2 and is a precursor to prostaglandins such as prostaglandins, thromboxanes, and prostacyclins, which act as autocrine and paracrine lipid mediators in the maintenance of local homeostasis by mediating vascular function, wound healing, and inflammation (52)
Their inclusion in the KLOW blend alongside GHK-Cu and KPV supports studies targeting multiple repair pathways simultaneously, enabling more comprehensive preclinical models than single-agent designs permit
14 Surveillance in the two years following treatment for SCC is particularly important as 70 80% of recurrent SCC develops within this time period
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