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The bladder mucosa has a strong barrier function that prevents drugs from passing through and remaining in the bladder

This changes the charge and structure of the peptide, affecting its biological activity

The majority of the published literature examines each compound independently, and the synergy hypothesis, while mechanistically well-supported, has not yet been the subject of large-scale controlled studies

For the investigation, a team led by Al-Aly sifted through the records of nearly 2 million people with diabetes who were treated by the Veterans Health Administration for an average of almost four years between October 2017 and the end of December 2023