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These mice were then randomly divided into eight groups (seven mice per group): a vehicle group, an MXD (MXD) group, an imidocarb (1%) group, a profavine (1%) group, an abemaciclib (1%) group, an aminoacridine (1.0%) group, an aminoacridine (0.3%) + MXD (0.3%) group, and an aminoacridine (1.0%) + MXD (0.3%) group

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In intact HepG2 cells, the pan-flavoenzyme inhibitor, DPI, prevented the NFT-stimulated increase in glutathione levels, indicating the involvement of one or more of these enzymes in NFT-dependent activation of Nrf2 (Fig

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