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Contraindications Known hypersensitivity to any of the components Not recommended during pregnancy or lactation without medical supervision Warnings & Precautions Keep out of reach of children Use cautiously in patients with renal impairment Not a substitute for a varied diet or treatment of chronic diseases Adverse Effects Generally well tolerated

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34 Consequently, turnover of 5,10-methyleneTHF via the TYMS enzyme is proposed to be greater in 3R3R individuals, with a decrease in this vitamer and an increase in homocysteine levels previously observed in such individuals