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Tissues and structures affected by knee OA include: The articular cartilage, a smooth surface covering the bones that reduces friction and serves as a shock absorber gradually breaks down and erodes

Findings suggest that binding at hypothalamic receptors may promote neuropeptides such as NPY and AgRP, both linked to hunger pathways

Around 60% of patients exhibit extra-thyroidal manifestations in which the eyes are affected (also known as Graves orbitopathy or Graves eye disease) [154]

In the present study, the effect of the increased ClpB on appetite is not clear, and inhibition of glycogenesis by increased LPS has not been examined