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Protocol [2] Rats: Serial dilutions of dihexa in 50% DMSO or water (for dilutions of 50 g/mL or less) are prepared from the stock used to dose the animals to be used for preparation of a standard curve

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FIGURE 4 GSTP1 Activity in GSH-Conjugation of AQ-QI and DEAQ-QI To investigate the intracellular GSTP1-mediated GSH-conjugation of AQ-QI or DEAQ-QI, AQ-SG, and DEAQ-SG formation were measured in total lysates directly after QI exposure

Likewise, kinetic analyses of 2-oxoglutarate transport in rat liver mitochondria indicated the presence of a single MichaelisMenten component with kinetic parameters in the range of those reported previously for kidney mitochondria (Zhong et al., 2008)