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A striking selectivity for AR binding sites based on the presence of adjacent binding motifs emerged in studies in which SUMO2 and 3 activity was inhibited pharmacologically: SUMOylation inhibition using ML-792 inhibited AR binding to genomic regions that contain multiple AREs, but enhanced AR binding to less accessible AREs that are enriched for pioneering transcription factor binding sites

Acta Biomater 195:297308 Chen J et al (2021) Enhanced HIFU theranostics with dual-frequency-ring focused ultrasound and activatable perfluoropentane-loaded polymer nanoparticles

Beers GJ, Nichols GR, Willing SJ, Reiss SJ

doi: 10.1016/j.autrev.2009.02.020