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(Antioxidant System) - : GSH (first-line antioxidant) Reactive Oxygen Species (ROS) Lipid Peroxides () - : GSH (Vitamin E) Lipid Peroxyl Radicals (LOO- ) Vitamin E (oxidized)+GSHVitamin E (reduced)+GSSG 2
These complexes facilitate the activation of caspase-3/7, cleavage of GSDMD and GSDME, and phosphorylation of MLKL, leading to membrane pore formation and the progression of PANoptosis [39]
10.1016/j.burns.2016.09.023 156 QuH.WuJ.PanY.AbdullaA.DuanZ.ChengW.et al (2024)
The main symptoms include: Physical fatigue : a constant feeling of exhaustion that does not go away even after adequate rest or sleep
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