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Medications That Influence Pigmentation Several medications are associated with melasma due to their impact on hormone levels or their ability to make the skin more sensitive to light
Compared to continued use of GLP-1s for three years, which corresponded to an 18% risk reduction, GLP-1 users who experienced interruption and subsequently resumed gained a 12% risk reduction on average
The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)
It can occur anywhere but is most common on the face, chest, and back
