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This limitation is also magnified by the varied design of the studies available including different supplementation protocols and outcome measures
For example, 3,3-Diindolylmethane (DIM) is sensitive to light during storage, and has limited solubility in water and physicochemical instability
Biochemical, serological, and genetic aspects related to gene HLA-DQB1 and its association with type 1 diabetes mellitus (T1DM)
It is likely that variations in experimental methods, biological systems, as well as the distinct metabolic characteristics of cells contributed to the variability in reported results 18,23
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